If you haven't got it already, you will need the latest version of the Focusrite Control software. This step is crucial and it is required for the interface to perform properly with your device.
You can find the latest version here. Make sure to install the correct one (Mac or PC) for your device.
Once downloaded and installed, close all other apps and leave open Focusrite Control only.
Click 'File' > 'Restore Factory Defaults' > OK - this will reset the interface to factory settings.
If prompted to choose a Preset, click off that window instead.
Make sure that your Audio Input and Output routing on your device's audio settings and your DAW audio settings are assigned to your interface.
FL Studio and Windows users: Select 'FOCUSRITE USB ASIO' as your audio driver.
- Reset the interface every session for the best results.
- Check the three green lights are on when your laptop is plugged into the interface. If the light isn’t on, chances are you’ve got the wrong USB cable plugged in.
- Ensure the yellow cables are plugged into outputs 1+2. If they're in 3+4 (easily done) then the interface ignores the master volume control and sends out audio at max gain, bad for ears and gear!